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== | ==Crystal Structure of FosB from Bacillus cereus with Maganese and Potential BSH-Fosfomycin Product== | ||
[[http://www.uniprot.org/uniprot/FOSB_BACC1 FOSB_BACC1 | <StructureSection load='4jh9' size='340' side='right'caption='[[4jh9]], [[Resolution|resolution]] 1.77Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_ATCC_10987 Bacillus cereus ATCC 10987]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JH9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KM:(2R)-2-AZANYL-3-[(1R,2S)-2-OXIDANYL-1-PHOSPHONO-PROPYL]SULFANYL-PROPANOIC+ACID'>1KM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jh9 OCA], [https://pdbe.org/4jh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jh9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FOSB_BACC1 FOSB_BACC1] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity). | |||
== | ==See Also== | ||
[[ | *[[Metallothiol transferase FosB|Metallothiol transferase FosB]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus cereus ATCC 10987]] | |||
[[Category: Bacillus cereus | [[Category: Large Structures]] | ||
[[Category: Armstrong | [[Category: Armstrong RN]] | ||
[[Category: Cook | [[Category: Cook PD]] | ||
[[Category: Harp | [[Category: Harp J]] | ||
[[Category: Jagessar | [[Category: Jagessar K]] | ||
[[Category: Keithly | [[Category: Keithly ME]] | ||
[[Category: Thompson | [[Category: Thompson MK]] | ||
Latest revision as of 15:03, 1 March 2024
Crystal Structure of FosB from Bacillus cereus with Maganese and Potential BSH-Fosfomycin ProductCrystal Structure of FosB from Bacillus cereus with Maganese and Potential BSH-Fosfomycin Product
Structural highlights
FunctionFOSB_BACC1 Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity). See Also |
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