4jfk: Difference between revisions

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{{STRUCTURE_4jfk|  PDB=4jfk  |  SCENE=  }}
===Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with (1S,6R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-10-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]-3,10-diazabicyclo[4.3.1]decan-2-one===
{{ABSTRACT_PUBMED_23647266}}


==Function==
==Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with (1S,6R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-10-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]-3,10-diazabicyclo[4.3.1]decan-2-one==
[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.  
<StructureSection load='4jfk' size='340' side='right'caption='[[4jfk]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jfk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JFK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JFK:(1S,6R)-3-[2-(3,4-DIMETHOXYPHENOXY)ETHYL]-10-[(2-OXO-2,3-DIHYDRO-1,3-BENZOTHIAZOL-6-YL)SULFONYL]-3,10-DIAZABICYCLO[4.3.1]DECAN-2-ONE'>JFK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jfk OCA], [https://pdbe.org/4jfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jfk RCSB], [https://www.ebi.ac.uk/pdbsum/4jfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jfk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.


==About this Structure==
==See Also==
[[4jfk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFK OCA].
*[[FKBP 3D structures|FKBP 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:023647266</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Bracher, A.]]
[[Category: Bracher A]]
[[Category: Fabian, A.]]
[[Category: Fabian A]]
[[Category: Gopalakrishnan, R.]]
[[Category: Gopalakrishnan R]]
[[Category: Hausch, F.]]
[[Category: Hausch F]]
[[Category: Hoogeland, B.]]
[[Category: Hoogeland B]]
[[Category: Kirschner, A.]]
[[Category: Kirschner A]]
[[Category: Koch, U.]]
[[Category: Koch U]]
[[Category: Kozany, C.]]
[[Category: Kozany C]]
[[Category: Kress, C.]]
[[Category: Kress C]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Fk-506 binding domain]]
[[Category: Hsp90 cochaperone]]
[[Category: Immunophiline]]
[[Category: Isomerase]]
[[Category: Peptidyl-prolyl isomerase]]

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