4je3: Difference between revisions

Latest revision as of 15:03, 1 March 2024

An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregationAn Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation

Structural highlights

4je3 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.282Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CENPL_YEAST Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.^[1] ^[2]

References

↑ Ghosh SK, Poddar A, Hajra S, Sanyal K, Sinha P. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics. 2001 Apr;265(2):249-57. PMID:11361335
↑ Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P. The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 2004 Aug;46(2):82-91. Epub 2004 Jul 6. PMID:15241623 doi:http://dx.doi.org/10.1007/s00294-004-0516-6

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Ghosh SK, Poddar A, Hajra S, Sanyal K, Sinha P. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics. 2001 Apr;265(2):249-57. PMID:11361335

[2] Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P. The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 2004 Aug;46(2):82-91. Epub 2004 Jul 6. PMID:15241623 doi:http://dx.doi.org/10.1007/s00294-004-0516-6

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4je3 is ON HOLD  until Paper Publication
+==An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation==
+<StructureSection load='4je3' size='340' side='right'caption='[[4je3]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
-Authors: Hinshaw, S.M., Harrison, S.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>
-Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.282&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [https://pdbe.org/4je3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [https://www.ebi.ac.uk/pdbsum/4je3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4je3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CENPL_YEAST CENPL_YEAST] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae]]
+[[Category: Harrison SC]]
+[[Category: Hinshaw SM]]

4je3: Difference between revisions

Latest revision as of 15:03, 1 March 2024

An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregationAn Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

4je3: Difference between revisions

Latest revision as of 15:03, 1 March 2024

An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregationAn Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search