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== | ==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309== | ||
[[http://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT | <StructureSection load='4j9z' size='340' side='right'caption='[[4j9z]], [[Resolution|resolution]] 1.66Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4j9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J9Z FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KP:(3E)-6,7-DICHLORO-3-(HYDROXYIMINO)-1,3-DIHYDRO-2H-INDOL-2-ONE'>1KP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9z OCA], [https://pdbe.org/4j9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j9z RCSB], [https://www.ebi.ac.uk/pdbsum/4j9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9z ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. | |||
== | ==See Also== | ||
[[ | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | ||
*[[Potassium channel 3D structures|Potassium channel 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Pascal | [[Category: Pascal JM]] | ||
[[Category: Zhang | [[Category: Zhang J-F]] | ||
[[Category: Zhang | [[Category: Zhang M]] | ||
Latest revision as of 15:02, 1 March 2024
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309
Structural highlights
FunctionKCNN2_RAT Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. See Also |
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