4j73: Difference between revisions

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-{{STRUCTURE_4j73|  PDB=4j73  |  SCENE=  }}
-===Crystal structure of beta'-COP/p25 complex===
-{{ABSTRACT_PUBMED_23481256}}
-==Function==
+==Crystal structure of beta'-COP/p25 complex==
-[[http://www.uniprot.org/uniprot/COPB2_YEAST COPB2_YEAST]] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.<ref>PMID:17101773</ref>  [[http://www.uniprot.org/uniprot/TMED9_BOVIN TMED9_BOVIN]] Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity).
+<StructureSection load='4j73' size='340' side='right'caption='[[4j73]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[4j73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J73 FirstGlance]. <br>
-[[4j73]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J73 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.439&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j73 OCA], [https://pdbe.org/4j73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j73 RCSB], [https://www.ebi.ac.uk/pdbsum/4j73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j73 ProSAT]</span></td></tr>
-==Reference==
+</table>
-<references group="xtra"/><references/>
+== Function ==
+[https://www.uniprot.org/uniprot/COPB2_YEAST COPB2_YEAST] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.<ref>PMID:17101773</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bos taurus]]
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Goldberg, J.]]
+[[Category: Goldberg J]]
-[[Category: Ma, W.]]
+[[Category: Ma W]]
-[[Category: Beta propeller]]
-[[Category: Coatomer cargo recognition]]
-[[Category: Dilysine motif]]
-[[Category: Er retrieval signal]]
-[[Category: Protein transport]]