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{{STRUCTURE_4j1w|  PDB=4j1w  |  SCENE=  }}
===Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP===


==About this Structure==
==Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP==
[[4j1w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1W OCA].  
<StructureSection load='4j1w' size='340' side='right'caption='[[4j1w]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4j1w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1W FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=FFQ:[(1R)-1-HYDROXYPROPYL]PHOSPHONIC+ACID'>FFQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1w OCA], [https://pdbe.org/4j1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1w RCSB], [https://www.ebi.ac.uk/pdbsum/4j1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPPE_STRWE HPPE_STRWE] Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.<ref>PMID:16015285</ref> <ref>PMID:16186494</ref>
 
==See Also==
*[[Epoxidase 3D structures|Epoxidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces wedmorensis]]
[[Category: Streptomyces wedmorensis]]
[[Category: Dey, M.]]
[[Category: Dey M]]
[[Category: Drennan, C L.]]
[[Category: Drennan CL]]
[[Category: 2-phosphono migration]]
[[Category: Cupin fold]]
[[Category: Hydroxypropylphosphonic acid epoxidase]]
[[Category: Metal binding protein]]
[[Category: Mononuclear non-heme iron enzyme]]
[[Category: Phosphono migration]]

Latest revision as of 15:00, 1 March 2024

Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPPCrystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP

Structural highlights

4j1w is a 3 chain structure with sequence from Streptomyces wedmorensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.72Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HPPE_STRWE Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.[1] [2]

See Also

References

  1. ↑ Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL. Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature. 2005 Oct 6;437(7060):838-44. Epub 2005 Jul 13. PMID:16015285 doi:http://dx.doi.org/10.1038/nature03924
  2. ↑ McLuskey K, Cameron S, Hammerschmidt F, Hunter WN. Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14221-6. Epub 2005 Sep 26. PMID:16186494

4j1w, resolution 2.72Å

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