4isq: Difference between revisions

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{{STRUCTURE_4isq|  PDB=4isq  |  SCENE=  }}
===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I===


==Function==
==Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I==
[[http://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.  
<StructureSection load='4isq' size='340' side='right'caption='[[4isq]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4isq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ISQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4isq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isq OCA], [https://pdbe.org/4isq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4isq RCSB], [https://www.ebi.ac.uk/pdbsum/4isq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9LBR1_CLOBO Q9LBR1_CLOBO]


==About this Structure==
==See Also==
[[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA].
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
__TOC__
</StructureSection>
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
[[Category: Berntsson, R P.A.]]
[[Category: Homo sapiens]]
[[Category: Dong, M.]]
[[Category: Large Structures]]
[[Category: Peng, L.]]
[[Category: Berntsson RP-A]]
[[Category: Stenmark, P.]]
[[Category: Dong M]]
[[Category: Svensson, L M.]]
[[Category: Peng L]]
[[Category: Membrane binding]]
[[Category: Stenmark P]]
[[Category: Synaptotagmin and ganglioside binding]]
[[Category: Svensson LM]]
[[Category: Toxin]]

Latest revision as of 14:59, 1 March 2024

Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin IBinding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I

Structural highlights

4isq is a 6 chain structure with sequence from Clostridium botulinum and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.65Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9LBR1_CLOBO

See Also

4isq, resolution 2.65Å

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