4ipf: Difference between revisions

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-[[Image:4ipf.jpg|left|200px]]
-{{STRUCTURE_4ipf|  PDB=4ipf  |  SCENE=  }}
+==The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337==
+<StructureSection load='4ipf' size='340' side='right'caption='[[4ipf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ipf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IPF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1F0:[(4S,5R)-2-(4-TERT-BUTYL-2-ETHOXYPHENYL)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIMETHYL-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]{4-[3-(METHYLSULFONYL)PROPYL]PIPERAZIN-1-YL}METHANONE'>1F0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ipf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipf OCA], [https://pdbe.org/4ipf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ipf RCSB], [https://www.ebi.ac.uk/pdbsum/4ipf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ipf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
-===The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337===
+==See Also==
+*[[MDM2 3D structures|MDM2 3D structures]]
-{{ABSTRACT_PUBMED_23400593}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[4ipf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPF OCA].
 [[Category: Xenopus laevis]]
-[[Category: Crowther, R.]]
+[[Category: Crowther R]]
-[[Category: Graves, B J.]]
+[[Category: Graves BJ]]
-[[Category: Kammlott, R U.]]
+[[Category: Kammlott RU]]
-[[Category: Lukacs, C.]]
+[[Category: Lukacs C]]
-[[Category: E3 ubiquitin ligase]]
-[[Category: Imidazoline]]
-[[Category: Ligase-antagonist complex]]
-[[Category: Mdm2]]
-[[Category: Nucleus]]
-[[Category: P53]]
-[[Category: Protein-protein interaction]]