4i1e: Difference between revisions

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-[[Image:4i1e.jpg|left|200px]]
-{{STRUCTURE_4i1e|  PDB=4i1e  |  SCENE=  }}
+==Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R==
+<StructureSection load='4i1e' size='340' side='right'caption='[[4i1e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4i1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1E FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1e OCA], [https://pdbe.org/4i1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1e RCSB], [https://www.ebi.ac.uk/pdbsum/4i1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1e ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
-===Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R===
+==See Also==
+*[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[4i1e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1E OCA].
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Oryctolagus cuniculus]]
-[[Category: Kimlicka, L.]]
+[[Category: Kimlicka L]]
-[[Category: Petegem, F Van.]]
+[[Category: Van Petegem F]]
-[[Category: Calcium channel]]
-[[Category: Er/sr membrane]]
-[[Category: Metal transport]]