4i03: Difference between revisions

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-{{STRUCTURE_4i03|  PDB=4i03  |  SCENE=  }}
-===Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor===
-{{ABSTRACT_PUBMED_23567804}}
-==Function==
+==Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor==
-[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
+<StructureSection load='4i03' size='340' side='right'caption='[[4i03]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4i03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I03 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L88:(4R,22R)-5,21-DIOXO-4,22-BIS({3-[4-(4-PHENYLTHIOPHEN-2-YL)PHENYL]PROPANOYL}AMINO)-10,13,16-TRIOXA-6,20-DIAZAPENTACOSANE-1,25-DIOIC+ACID'>L88</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i03 OCA], [https://pdbe.org/4i03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i03 RCSB], [https://www.ebi.ac.uk/pdbsum/4i03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i03 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
-==About this Structure==
+==See Also==
-[[4i03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I03 OCA].
+*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Macrophage elastase]]
+[[Category: Large Structures]]
-[[Category: Cassar-Lajeunesse, E.]]
+[[Category: Cassar-Lajeunesse E]]
-[[Category: Devel, L.]]
+[[Category: Devel L]]
-[[Category: Dive, V.]]
+[[Category: Dive V]]
-[[Category: Stura, E A.]]
+[[Category: Stura EA]]
-[[Category: Vera, L.]]
+[[Category: Vera L]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Metzincin]]
-[[Category: Selective carboxylate based mmp-12 bifunctional inhibitor]]
-[[Category: Zinc protease]]