4hid: Difference between revisions

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[[Image:4hid.jpg|left|200px]]


{{STRUCTURE_4hid|  PDB=4hid  |  SCENE=  }}
==Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GCTTACGGT)==
 
<StructureSection load='4hid' size='340' side='right'caption='[[4hid]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
===Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GCTTACGGT)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4hid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HID FirstGlance]. <br>
{{ABSTRACT_PUBMED_23201273}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.822&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hid OCA], [https://pdbe.org/4hid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hid RCSB], [https://www.ebi.ac.uk/pdbsum/4hid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hid ProSAT]</span></td></tr>
==About this Structure==
</table>
[[4hid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HID OCA].  
== Function ==
[https://www.uniprot.org/uniprot/POT1_SCHPO POT1_SCHPO] Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.<ref>PMID:11349150</ref> <ref>PMID:12463756</ref> <ref>PMID:18535244</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Dickey, T H.]]
[[Category: Dickey TH]]
[[Category: Wuttke, D S.]]
[[Category: Wuttke DS]]
[[Category: Dna binding protein]]
[[Category: Dna-binding]]
[[Category: Ob-fold]]
[[Category: Plasticity]]
[[Category: Promiscuity]]
[[Category: Specificity]]
[[Category: Telomeric dna]]

Latest revision as of 14:41, 1 March 2024

Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GCTTACGGT)Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GCTTACGGT)

Structural highlights

4hid is a 2 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.822Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

POT1_SCHPO Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.[1] [2] [3]

References

  1. ↑ Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 2001 May 11;292(5519):1171-5. PMID:11349150 doi:http://dx.doi.org/10.1126/science.1060036
  2. ↑ Lei M, Baumann P, Cech TR. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 2002 Dec 10;41(49):14560-8. PMID:12463756
  3. ↑ Miyoshi T, Kanoh J, Saito M, Ishikawa F. Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science. 2008 Jun 6;320(5881):1341-4. doi: 10.1126/science.1154819. PMID:18535244 doi:http://dx.doi.org/10.1126/science.1154819

4hid, resolution 1.82Å

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