4hfh: Difference between revisions
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New page: '''Unreleased structure''' The entry 4hfh is ON HOLD Authors: Sauguet, L., Howard, R.J., Malherbe, L., Lee, U.S., Corringer, P.J., Harris, R.A., Delarue, M. Description: The GLIC penta... |
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The | ==The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform== | ||
<StructureSection load='4hfh' size='340' side='right'caption='[[4hfh]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hfh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HFH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MBR:TRIBROMOMETHANE'>MBR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfh OCA], [https://pdbe.org/4hfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hfh RCSB], [https://www.ebi.ac.uk/pdbsum/4hfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hfh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | |||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gloeobacter violaceus PCC 7421]] | |||
[[Category: Large Structures]] | |||
[[Category: Corringer PJ]] | |||
[[Category: Delarue M]] | |||
[[Category: Harris RA]] | |||
[[Category: Howard RJ]] | |||
[[Category: Lee US]] | |||
[[Category: Malherbe L]] | |||
[[Category: Sauguet L]] | |||
Latest revision as of 14:40, 1 March 2024
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoformThe GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform
Structural highlights
FunctionGLIC_GLOVI Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1] See AlsoReferences
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