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{{STRUCTURE_4han|  PDB=4han  |  SCENE=  }}
===Crystal structure of Galectin 8 with NDP52 peptide===
{{ABSTRACT_PUBMED_23511477}}


==Function==
==Crystal structure of Galectin 8 with NDP52 peptide==
[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref> [[http://www.uniprot.org/uniprot/CACO2_HUMAN CACO2_HUMAN]] May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.<ref>PMID:17635994</ref>
<StructureSection load='4han' size='340' side='right'caption='[[4han]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4han]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4han FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4han OCA], [https://pdbe.org/4han PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4han RCSB], [https://www.ebi.ac.uk/pdbsum/4han PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4han ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>  


==About this Structure==
==See Also==
[[4han]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alfaropsis_roxburghiana Alfaropsis roxburghiana] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAN OCA].
*[[Galectin 3D structures|Galectin 3D structures]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
[[Category: Alfaropsis roxburghiana]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hong, S B.]]
[[Category: Large Structures]]
[[Category: Kim, B W.]]
[[Category: Hong SB]]
[[Category: Kim, J H.]]
[[Category: Kim B-W]]
[[Category: Kwon, D H.]]
[[Category: Kim JH]]
[[Category: Song, H K.]]
[[Category: Kwon DH]]
[[Category: Autophagy]]
[[Category: Song HK]]
[[Category: Autophagy adapter molecule]]
[[Category: Cytosol]]
[[Category: Innate immunity]]
[[Category: Nad binding]]
[[Category: Ndp52 peoptide binding]]
[[Category: Sugar binding protein]]

Latest revision as of 14:36, 1 March 2024

Crystal structure of Galectin 8 with NDP52 peptideCrystal structure of Galectin 8 with NDP52 peptide

Structural highlights

4han is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.551Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEG8_HUMAN Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.[1]

See Also

References

  1. ↑ Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K. Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J Biol Chem. 2011 Apr 1;286(13):11346-55. Epub 2011 Feb 2. PMID:21288902 doi:10.1074/jbc.M110.195925

4han, resolution 2.55Å

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