4gzn: Difference between revisions

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[[Image:4gzn.png|left|200px]]


{{STRUCTURE_4gzn|  PDB=4gzn  |  SCENE=  }}
==Mouse ZFP57 zinc fingers in complex with methylated DNA==
 
<StructureSection load='4gzn' size='340' side='right'caption='[[4gzn]], [[Resolution|resolution]] 0.99&Aring;' scene=''>
===Mouse ZFP57 zinc fingers in complex with methylated DNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4gzn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZN FirstGlance]. <br>
{{ABSTRACT_PUBMED_23059534}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.99&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzn OCA], [https://pdbe.org/4gzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzn RCSB], [https://www.ebi.ac.uk/pdbsum/4gzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzn ProSAT]</span></td></tr>
[[4gzn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZN OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZFP57_MOUSE ZFP57_MOUSE] Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.<ref>PMID:15070898</ref> <ref>PMID:18854139</ref> <ref>PMID:23059534</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Cheng, X.]]
[[Category: Cheng X]]
[[Category: Liu, Y.]]
[[Category: Liu Y]]
[[Category: Zhang, X.]]
[[Category: Zhang X]]
[[Category: Transcription-dna complex]]
[[Category: Zinc finger]]

Latest revision as of 14:35, 1 March 2024

Mouse ZFP57 zinc fingers in complex with methylated DNAMouse ZFP57 zinc fingers in complex with methylated DNA

Structural highlights

4gzn is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.99Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZFP57_MOUSE Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.[1] [2] [3]

References

  1. ↑ Alonso MB, Zoidl G, Taveggia C, Bosse F, Zoidl C, Rahman M, Parmantier E, Dean CH, Harris BS, Wrabetz L, Muller HW, Jessen KR, Mirsky R. Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system. J Biol Chem. 2004 Jun 11;279(24):25653-64. Epub 2004 Apr 7. PMID:15070898 doi:http://dx.doi.org/10.1074/jbc.M400415200
  2. ↑ Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell. 2008 Oct;15(4):547-57. doi: 10.1016/j.devcel.2008.08.014. PMID:18854139 doi:http://dx.doi.org/10.1016/j.devcel.2008.08.014
  3. ↑ Liu Y, Toh H, Sasaki H, Zhang X, Cheng X. An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev. 2012 Nov 1;26(21):2374-9. doi: 10.1101/gad.202200.112. Epub 2012 Oct, 11. PMID:23059534 doi:http://dx.doi.org/10.1101/gad.202200.112

4gzn, resolution 0.99Å

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