4gcs: Difference between revisions

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[[Image:4gcs.png|left|200px]]


{{STRUCTURE_4gcs| PDB=4gcs | SCENE= }}  
==Crystal Structure of E. coli OmpF porin in complex with Ertapenem==
<StructureSection load='4gcs' size='340' side='right'caption='[[4gcs]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gcs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GCS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1RG:(4R,5S)-3-({(3S,5S)-5-[(3-CARBOXYPHENYL)CARBAMOYL]PYRROLIDIN-3-YL}SULFANYL)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-4-METHYL-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>1RG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcs OCA], [https://pdbe.org/4gcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gcs RCSB], [https://www.ebi.ac.uk/pdbsum/4gcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>


===Crystal Structure of E. coli OmpF porin in complex with Ertapenem===
==See Also==
 
*[[Porin 3D structures|Porin 3D structures]]
{{ABSTRACT_PUBMED_23201272}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[4gcs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCS OCA].
</StructureSection>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli K-12]]
[[Category: Roux, B.]]
[[Category: Large Structures]]
[[Category: Ziervogel, B K.]]
[[Category: Roux B]]
[[Category: Beta-barrel]]
[[Category: Ziervogel BK]]
[[Category: Ertapenem binding]]
[[Category: Membrane protein-antibiotic complex]]
[[Category: Non-specific channel]]
[[Category: Outer membrane]]
[[Category: Protein-drug complex]]
[[Category: Trimer]]

Latest revision as of 14:27, 1 March 2024

Crystal Structure of E. coli OmpF porin in complex with ErtapenemCrystal Structure of E. coli OmpF porin in complex with Ertapenem

Structural highlights

4gcs is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.87Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OMPF_ECOLI Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.[1]

See Also

References

  1. ↑ Duval V, Nicoloff H, Levy SB. Combined inactivation of lon and ycgE decreases multidrug susceptibility by reducing the amount of OmpF porin in Escherichia coli. Antimicrob Agents Chemother. 2009 Nov;53(11):4944-8. doi: 10.1128/AAC.00787-09., Epub 2009 Aug 31. PMID:19721064 doi:10.1128/AAC.00787-09

4gcs, resolution 1.87Å

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