4ga2: Difference between revisions
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==Structure of the N-terminal domain of Nup358== | |||
<StructureSection load='4ga2' size='340' side='right'caption='[[4ga2]], [[Resolution|resolution]] 0.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ga2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga2 OCA], [https://pdbe.org/4ga2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga2 ProSAT]</span></td></tr> | |||
== | </table> | ||
[[4ga2]] is a 1 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/RBP2_PANTR RBP2_PANTR] E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (By similarity). Binds single-stranded RNA (in vitro).<ref>PMID:22959972</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pan troglodytes]] | [[Category: Pan troglodytes]] | ||
[[Category: Hoelz | [[Category: Hoelz A]] | ||
[[Category: Kassube | [[Category: Kassube SA]] | ||
[[Category: Lin | [[Category: Lin DH]] | ||
[[Category: Stuwe | [[Category: Stuwe T]] | ||
Latest revision as of 14:26, 1 March 2024
Structure of the N-terminal domain of Nup358Structure of the N-terminal domain of Nup358
Structural highlights
FunctionRBP2_PANTR E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (By similarity). Binds single-stranded RNA (in vitro).[1] References
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