4ga2: Difference between revisions

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'''Unreleased structure'''


The entry 4ga2 is ON HOLD  until Paper Publication
==Structure of the N-terminal domain of Nup358==
 
<StructureSection load='4ga2' size='340' side='right'caption='[[4ga2]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
Authors: Hoelz, A., Kassube, S.A., Lin, D.H., Stuwe, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ga2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA2 FirstGlance]. <br>
Description: Structure of Nucleoporin Complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga2 OCA], [https://pdbe.org/4ga2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBP2_PANTR RBP2_PANTR] E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (By similarity). Binds single-stranded RNA (in vitro).<ref>PMID:22959972</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pan troglodytes]]
[[Category: Hoelz A]]
[[Category: Kassube SA]]
[[Category: Lin DH]]
[[Category: Stuwe T]]

Latest revision as of 14:26, 1 March 2024

Structure of the N-terminal domain of Nup358Structure of the N-terminal domain of Nup358

Structural highlights

4ga2 is a 1 chain structure with sequence from Pan troglodytes. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.95Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RBP2_PANTR E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (By similarity). Binds single-stranded RNA (in vitro).[1]

References

  1. ↑ Kassube SA, Stuwe T, Lin DH, Antonuk CD, Napetschnig J, Blobel G, Hoelz A. Crystal Structure of the N-Terminal Domain of Nup358/RanBP2. J Mol Biol. 2012 Sep 7. pii: S0022-2836(12)00719-X. doi:, 10.1016/j.jmb.2012.08.026. PMID:22959972 doi:http://dx.doi.org/10.1016/j.jmb.2012.08.026

4ga2, resolution 0.95Å

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