4fl0: Difference between revisions

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[[Image:4fl0.jpg|left|200px]]


{{STRUCTURE_4fl0|  PDB=4fl0  |  SCENE=  }}
==Crystal structure of ALD1 from Arabidopsis thaliana==
 
<StructureSection load='4fl0' size='340' side='right'caption='[[4fl0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal structure of ALD1 from Arabidopsis thaliana===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4fl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FL0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_23385743}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fl0 OCA], [https://pdbe.org/4fl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fl0 RCSB], [https://www.ebi.ac.uk/pdbsum/4fl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fl0 ProSAT]</span></td></tr>
[[4fl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL0 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALD1_ARATH ALD1_ARATH] Aminotransferase involved in local and systemic acquired resistance (SAR) to the bacterial pathogen P.syringae. Required for salicylic acid (SA) and camalexin accumulation upon pathogen infection. Possesses aminotransferase activity in vitro and may generate amino-acid-derived defense signals in vivo. May be involved in ethylene-induced senescence signaling.<ref>PMID:14729919</ref> <ref>PMID:15447647</ref> <ref>PMID:19825557</ref> <ref>PMID:18266921</ref> <ref>PMID:21530897</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Albeck, S.]]
[[Category: Large Structures]]
[[Category: Dym, O.]]
[[Category: Albeck S]]
[[Category: Edelman, M.]]
[[Category: Dym O]]
[[Category: Galili, G.]]
[[Category: Edelman M]]
[[Category: ISPC, Israel Structural Proteomics Center.]]
[[Category: Galili G]]
[[Category: Kirma, M.]]
[[Category: Kirma M]]
[[Category: Sobolev, V.]]
[[Category: Sobolev V]]
[[Category: Unger, T.]]
[[Category: Unger T]]
[[Category: ISPC]]
[[Category: Israel Structural Proteomics Center]]
[[Category: Pathogen resistance]]
[[Category: Plp nbinding]]
[[Category: Protein structure initiative]]
[[Category: Sandwich fold and architecture]]
[[Category: Structural genomic]]
[[Category: Transferase]]

Latest revision as of 14:17, 1 March 2024

Crystal structure of ALD1 from Arabidopsis thalianaCrystal structure of ALD1 from Arabidopsis thaliana

Structural highlights

4fl0 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALD1_ARATH Aminotransferase involved in local and systemic acquired resistance (SAR) to the bacterial pathogen P.syringae. Required for salicylic acid (SA) and camalexin accumulation upon pathogen infection. Possesses aminotransferase activity in vitro and may generate amino-acid-derived defense signals in vivo. May be involved in ethylene-induced senescence signaling.[1] [2] [3] [4] [5]

References

  1. ↑ Song JT, Lu H, Greenberg JT. Divergent roles in Arabidopsis thaliana development and defense of two homologous genes, aberrant growth and death2 and AGD2-LIKE DEFENSE RESPONSE PROTEIN1, encoding novel aminotransferases. Plant Cell. 2004 Feb;16(2):353-66. Epub 2004 Jan 16. PMID:14729919 doi:10.1105/tpc.019372
  2. ↑ Song JT, Lu H, McDowell JM, Greenberg JT. A key role for ALD1 in activation of local and systemic defenses in Arabidopsis. Plant J. 2004 Oct;40(2):200-12. PMID:15447647 doi:10.1111/j.1365-313X.2004.02200.x
  3. ↑ Zhang Z, Lenk A, Andersson MX, Gjetting T, Pedersen C, Nielsen ME, Newman MA, Hou BH, Somerville SC, Thordal-Christensen H. A lesion-mimic syntaxin double mutant in Arabidopsis reveals novel complexity of pathogen defense signaling. Mol Plant. 2008 May;1(3):510-27. doi: 10.1093/mp/ssn011. Epub 2008 Apr 15. PMID:19825557 doi:10.1093/mp/ssn011
  4. ↑ Lee MW, Jelenska J, Greenberg JT. Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1. Plant J. 2008 May;54(3):452-65. doi: 10.1111/j.1365-313X.2008.03439.x. Epub 2008 , Feb 7. PMID:18266921 doi:10.1111/j.1365-313X.2008.03439.x
  5. ↑ Nie H, Wu Y, Yao C, Tang D. Suppression of edr2-mediated powdery mildew resistance, cell death and ethylene-induced senescence by mutations in ALD1 in Arabidopsis. J Genet Genomics. 2011 Apr 20;38(4):137-48. doi: 10.1016/j.jgg.2011.03.001. Epub , 2011 Mar 23. PMID:21530897 doi:10.1016/j.jgg.2011.03.001

4fl0, resolution 2.30Å

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