4ffs: Difference between revisions

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-'''Unreleased structure'''
-The entry 4ffs is ON HOLD  until Paper Publication
+==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A==
+<StructureSection load='4ffs' size='340' side='right'caption='[[4ffs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Haapalainen, A.M., Rinaldo-Matthis, A., Brown, R.L., Norris, G.E., Almo, S.C., Schramm, V.L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ffs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFS FirstGlance]. <br>
-Description: Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIG:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(BUTYLSULFANYL)METHYL]PYRROLIDIN-3-OL'>BIG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffs OCA], [https://pdbe.org/4ffs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffs RCSB], [https://www.ebi.ac.uk/pdbsum/4ffs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Helicobacter pylori J99]]
+[[Category: Large Structures]]
+[[Category: Almo SC]]
+[[Category: Brown RL]]
+[[Category: Haapalainen AM]]
+[[Category: Norris GE]]
+[[Category: Rinaldo-Matthis A]]
+[[Category: Schramm VL]]