4f9a: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4f9a is ON HOLD  until Paper Publication
+==Human CDC7 kinase in complex with DBF4 and nucleotide==
+<StructureSection load='4f9a' size='340' side='right'caption='[[4f9a]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
-Authors: Hughes, S., Cherepanov, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4f9a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F9A FirstGlance]. <br>
-Description: Human CDC7 kinase in complex with DBF4 and nucleotide
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f9a OCA], [https://pdbe.org/4f9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f9a RCSB], [https://www.ebi.ac.uk/pdbsum/4f9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f9a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CDC7_HUMAN CDC7_HUMAN] Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.<ref>PMID:12065429</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cherepanov P]]
+[[Category: Hughes S]]