4f6m: Difference between revisions

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[[Image:4f6m.png|left|200px]]


{{STRUCTURE_4f6m|  PDB=4f6m  |  SCENE=  }}
==Crystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA==
 
<StructureSection load='4f6m' size='340' side='right'caption='[[4f6m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Crystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4f6m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F6M FirstGlance]. <br>
{{ABSTRACT_PUBMED_22949637}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f6m OCA], [https://pdbe.org/4f6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f6m RCSB], [https://www.ebi.ac.uk/pdbsum/4f6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f6m ProSAT]</span></td></tr>
[[4f6m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6M OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Buck-Koehntop, B A.]]
[[Category: Large Structures]]
[[Category: Dyson, H J.]]
[[Category: Buck-Koehntop BA]]
[[Category: Ekiert, D C.]]
[[Category: Dyson HJ]]
[[Category: Martinez-Yamout, M A.]]
[[Category: Ekiert DC]]
[[Category: Stanfield, R L.]]
[[Category: Martinez-Yamout MA]]
[[Category: Wilson, I A.]]
[[Category: Stanfield RL]]
[[Category: Wright, P E.]]
[[Category: Wilson IA]]
[[Category: Dna]]
[[Category: Wright PE]]
[[Category: Dna binding]]
[[Category: Dna binding protein-dna complex]]
[[Category: Double helix]]
[[Category: Protein-dna complex]]
[[Category: Zinc finger]]

Latest revision as of 14:11, 1 March 2024

Crystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNACrystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA

Structural highlights

4f6m is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAISO_HUMAN Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.[1] [2] [3] [4]

References

  1. ↑ Prokhortchouk A, Hendrich B, Jorgensen H, Ruzov A, Wilm M, Georgiev G, Bird A, Prokhortchouk E. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev. 2001 Jul 1;15(13):1613-8. PMID:11445535 doi:10.1101/gad.198501
  2. ↑ Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell. 2003 Sep;12(3):723-34. PMID:14527417
  3. ↑ Ruzov A, Dunican DS, Prokhortchouk A, Pennings S, Stancheva I, Prokhortchouk E, Meehan RR. Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. Development. 2004 Dec;131(24):6185-94. Epub 2004 Nov 17. PMID:15548582 doi:dev.01549
  4. ↑ Spring CM, Kelly KF, O'Kelly I, Graham M, Crawford HC, Daniel JM. The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res. 2005 May 1;305(2):253-65. PMID:15817151 doi:S0014-4827(05)00014-5

4f6m, resolution 2.40Å

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