4f14: Difference between revisions

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[[Image:4f14.jpg|left|200px]]


{{STRUCTURE_4f14|  PDB=4f14  |  SCENE=  }}
==Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2==
 
<StructureSection load='4f14' size='340' side='right'caption='[[4f14]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
===Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4f14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F14 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[4f14]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F14 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f14 OCA], [https://pdbe.org/4f14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f14 RCSB], [https://www.ebi.ac.uk/pdbsum/4f14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f14 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEBL_HUMAN NEBL_HUMAN] Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.<ref>PMID:15004028</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Sauer, F.]]
[[Category: Large Structures]]
[[Category: Vahokoski, J.]]
[[Category: Sauer F]]
[[Category: Wilmanns, M.]]
[[Category: Vahokoski J]]
[[Category: Actin-binding protein-peptide complex]]
[[Category: Wilmanns M]]
[[Category: Heart muscle]]
[[Category: Sh3 domain]]

Latest revision as of 14:07, 1 March 2024

Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2

Structural highlights

4f14 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NEBL_HUMAN Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.[1]

References

  1. ↑ Li B, Zhuang L, Trueb B. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. J Biol Chem. 2004 May 7;279(19):20401-10. Epub 2004 Mar 5. PMID:15004028 doi:10.1074/jbc.M310304200

4f14, resolution 1.20Å

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