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==Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin== | |||
<StructureSection load='4ezn' size='340' side='right'caption='[[4ezn]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ezn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Pyrrhocoris_apterus Pyrrhocoris apterus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezn OCA], [https://pdbe.org/4ezn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezn RCSB], [https://www.ebi.ac.uk/pdbsum/4ezn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] | |||
==See Also== | |||
*[[Heat Shock Protein structures|Heat Shock Protein structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Pyrrhocoris apterus]] | |||
[[Category: Straeter N]] | |||
[[Category: Zahn M]] | |||
Latest revision as of 14:07, 1 March 2024
Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricinCrystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin
Structural highlights
FunctionDNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] See Also |
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