4ezd: Difference between revisions

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[[Image:4ezd.jpg|left|200px]]


{{STRUCTURE_4ezd| PDB=4ezd | SCENE= }}
==Crystal Structure of the UT-B Urea Transporter from Bos Taurus Bound to Selenourea==
<StructureSection load='4ezd' size='340' side='right'caption='[[4ezd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ezd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SEY:SELENOUREA'>SEY</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezd OCA], [https://pdbe.org/4ezd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezd RCSB], [https://www.ebi.ac.uk/pdbsum/4ezd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref>


===Crystal Structure of the UT-B Urea Transporter from Bos Taurus Bound to Selenourea===
==See Also==
 
*[[Urea transporter|Urea transporter]]
 
== References ==
==About this Structure==
<references/>
[[4ezd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZD OCA].
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Cao, Y.]]
[[Category: Large Structures]]
[[Category: Levin, E J.]]
[[Category: Cao Y]]
[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure.]]
[[Category: Levin EJ]]
[[Category: Zhou, M.]]
[[Category: Zhou M]]
[[Category: Channel]]
[[Category: Membrane protein]]
[[Category: New york consortium on membrane protein structure]]
[[Category: Nycomp]]
[[Category: Psi-biology]]
[[Category: Slc14]]
[[Category: Structural genomic]]
[[Category: Transport protein]]
[[Category: Urea transport]]

Latest revision as of 14:07, 1 March 2024

Crystal Structure of the UT-B Urea Transporter from Bos Taurus Bound to SelenoureaCrystal Structure of the UT-B Urea Transporter from Bos Taurus Bound to Selenourea

Structural highlights

4ezd is a 3 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UT1_BOVIN Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.[1] [2]

See Also

References

  1. ↑ Stewart GS, Graham C, Cattell S, Smith TP, Simmons NL, Smith CP. UT-B is expressed in bovine rumen: potential role in ruminal urea transport. Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R605-R612. Epub, 2005 Apr 21. PMID:15845882 doi:http://dx.doi.org/00127.2005
  2. ↑ Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 2012 Jun 25. PMID:22733730 doi:10.1073/pnas.1207362109

4ezd, resolution 2.50Å

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