4eyb: Difference between revisions

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[[Image:4eyb.jpg|left|200px]]


{{STRUCTURE_4eyb| PDB=4eyb | SCENE= }}  
==Crystal structure of NDM-1 bound to hydrolyzed oxacillin==
<StructureSection load='4eyb' size='340' side='right'caption='[[4eyb]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4eyb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WO:(2R,4S)-2-[(R)-CARBOXY{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>0WO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyb OCA], [https://pdbe.org/4eyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyb RCSB], [https://www.ebi.ac.uk/pdbsum/4eyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.


===Crystal structure of NDM-1 bound to hydrolyzed oxacillin===
==See Also==
 
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
{{ABSTRACT_PUBMED_22713171}}
__TOC__
 
</StructureSection>
==About this Structure==
[[4eyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYB OCA].
 
==Reference==
<ref group="xtra">PMID:022713171</ref><references group="xtra"/>
[[Category: Beta-lactamase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
[[Category: King, D T.]]
[[Category: Large Structures]]
[[Category: Strynadka, N C.J.]]
[[Category: King DT]]
[[Category: Antibiotic]]
[[Category: Strynadka NCJ]]
[[Category: Hydrolase-antibiotic complex]]
[[Category: Metallo beta lactamase]]

Latest revision as of 14:06, 1 March 2024

Crystal structure of NDM-1 bound to hydrolyzed oxacillinCrystal structure of NDM-1 bound to hydrolyzed oxacillin

Structural highlights

4eyb is a 2 chain structure with sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.16Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BLAN1_KLEPN Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

See Also

4eyb, resolution 1.16Å

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