4ey2: Difference between revisions
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New page: '''Unreleased structure''' The entry 4ey2 is ON HOLD Authors: Strynadka, N.C.J., King, D.T. Description: Hydrolase 1c |
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==Crystal structure of NDM-1 bound to hydrolyzed methicillin== | |||
<StructureSection load='4ey2' size='340' side='right'caption='[[4ey2]], [[Resolution|resolution]] 1.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ey2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EY2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.17Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RM:(2R,4S)-2-{(R)-CARBOXY[(2,6-DIMETHOXYBENZOYL)AMINO]METHYL}-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>0RM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ey2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ey2 OCA], [https://pdbe.org/4ey2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ey2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ey2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ey2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
==See Also== | |||
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klebsiella pneumoniae]] | |||
[[Category: Large Structures]] | |||
[[Category: King DT]] | |||
[[Category: Strynadka NCJ]] | |||
Latest revision as of 14:06, 1 March 2024
Crystal structure of NDM-1 bound to hydrolyzed methicillinCrystal structure of NDM-1 bound to hydrolyzed methicillin
Structural highlights
FunctionBLAN1_KLEPN Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. See Also |
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