4es0: Difference between revisions

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-[[Image:4es0.jpg|left|200px]]
-<!--
+==X-ray structure of WDR5-SETd1b Win motif peptide binary complex==
-The line below this paragraph, containing "STRUCTURE_4es0", creates the "Structure Box" on the page.
+<StructureSection load='4es0' size='340' side='right'caption='[[4es0]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[4es0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ES0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.817&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4es0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4es0 OCA], [https://pdbe.org/4es0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4es0 RCSB], [https://www.ebi.ac.uk/pdbsum/4es0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4es0 ProSAT]</span></td></tr>
-{{STRUCTURE_4es0|  PDB=4es0  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
-===X-ray structure of WDR5-SETd1b Win motif peptide binary complex===
+==See Also==
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[4es0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES0 OCA].
+__TOC__
-[[Category: Histone-lysine N-methyltransferase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Cosgrove, M S.]]
+[[Category: Large Structures]]
-[[Category: Dharmarajan, V.]]
+[[Category: Cosgrove MS]]
-[[Category: Lee, J H.]]
+[[Category: Dharmarajan V]]
-[[Category: Patel, A.]]
+[[Category: Lee J-H]]
-[[Category: Skalnik, D G.]]
+[[Category: Patel A]]
-[[Category: 3-10 helix]]
+[[Category: Skalnik DG]]
-[[Category: Ash2l]]
-[[Category: Beta propeller]]
-[[Category: Core complex]]
-[[Category: Histone]]
-[[Category: Lysine methyltransferase]]
-[[Category: Mll1]]
-[[Category: Rbbp5]]
-[[Category: Setd1b]]
-[[Category: Transcription-transferase complex]]
-[[Category: Wd40]]
-[[Category: Win motif]]