4er5: Difference between revisions
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==Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777== | ==Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777== | ||
<StructureSection load='4er5' size='340' side='right' caption='[[4er5]], [[Resolution|resolution]] 2.57Å' scene=''> | <StructureSection load='4er5' size='340' side='right'caption='[[4er5]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4er5]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4er5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER5 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er5 OCA], [https://pdbe.org/4er5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er5 RCSB], [https://www.ebi.ac.uk/pdbsum/4er5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er5 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | ||
==See Also== | ==See Also== | ||
*[[Histone methyltransferase|Histone methyltransferase]] | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Bradner | [[Category: Bountra C]] | ||
[[Category: Brown | [[Category: Bradner JE]] | ||
[[Category: Edwards | [[Category: Brown PJ]] | ||
[[Category: Federation | [[Category: Edwards AM]] | ||
[[Category: Li | [[Category: Federation A]] | ||
[[Category: Marineau | [[Category: Li Y]] | ||
[[Category: Nguyen | [[Category: Marineau J]] | ||
[[Category: Qi | [[Category: Nguyen KT]] | ||
[[Category: Qi J]] | |||
[[Category: Schapira | [[Category: Schapira M]] | ||
[[Category: Scopton | [[Category: Scopton A]] | ||
[[Category: Tempel | [[Category: Tempel W]] | ||
[[Category: Vedadi | [[Category: Vedadi M]] | ||
[[Category: Wernimont | [[Category: Wernimont AK]] | ||
[[Category: Yu | [[Category: Yu W]] | ||
Latest revision as of 14:05, 1 March 2024
Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777
Structural highlights
FunctionDOT1L_HUMAN Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. See Also |
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