4er0: Difference between revisions
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New page: '''Unreleased structure''' The entry 4er0 is ON HOLD Authors: Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Federation, A., Marineau, J., Qi, J., Vedadi, M., B... |
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==Crystal Structure of human DOT1L in complex with inhibitor FED1== | |||
<StructureSection load='4er0' size='340' side='right'caption='[[4er0]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4er0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AW1:5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXYADENOSINE'>AW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er0 OCA], [https://pdbe.org/4er0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er0 RCSB], [https://www.ebi.ac.uk/pdbsum/4er0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | |||
==See Also== | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Bradner JE]] | |||
[[Category: Brown PJ]] | |||
[[Category: Edwards AM]] | |||
[[Category: Federation A]] | |||
[[Category: Li Y]] | |||
[[Category: Marineau J]] | |||
[[Category: Nguyen KT]] | |||
[[Category: Qi J]] | |||
[[Category: Schapira M]] | |||
[[Category: Tempel W]] | |||
[[Category: Vedadi M]] | |||
[[Category: Wernimont AK]] | |||
[[Category: Yu W]] | |||
Latest revision as of 14:04, 1 March 2024
Crystal Structure of human DOT1L in complex with inhibitor FED1Crystal Structure of human DOT1L in complex with inhibitor FED1
Structural highlights
FunctionDOT1L_HUMAN Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. See Also |
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