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==Crystal structure of E. faecalis DNA ligase with inhibitor== | |||
<StructureSection load='4eeq' size='340' side='right'caption='[[4eeq]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4eeq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EEQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0OX:4-AMINO-2-(CYCLOPENTYLOXY)PYRIMIDINE-5-CARBOXAMIDE'>0OX</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eeq OCA], [https://pdbe.org/4eeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eeq RCSB], [https://www.ebi.ac.uk/pdbsum/4eeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eeq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | |||
==See Also== | |||
*[[DNA ligase 3D structures|DNA ligase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Enterococcus faecalis]] | |||
[[Category: Large Structures]] | |||
[[Category: Charifson P]] | |||
[[Category: Wang T]] | |||
[[Category: Wei Y]] | |||
Latest revision as of 14:03, 1 March 2024
Crystal structure of E. faecalis DNA ligase with inhibitorCrystal structure of E. faecalis DNA ligase with inhibitor
Structural highlights
FunctionDNLJ_ENTFA DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). See Also |
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