4ece: Difference between revisions

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-{{STRUCTURE_4ece|  PDB=4ece  |  SCENE=  }}
-===Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine===
-{{ABSTRACT_PUBMED_23438750}}
-==About this Structure==
+==Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine==
-[[4ece]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA].
+<StructureSection load='4ece' size='340' side='right'caption='[[4ece]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECE FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [https://pdbe.org/4ece PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [https://www.ebi.ac.uk/pdbsum/4ece PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ece ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
+==See Also==
+*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Purine-nucleoside phosphorylase]]
+[[Category: Large Structures]]
-[[Category: Almo, S C.]]
+[[Category: Almo SC]]
-[[Category: Haapalainen, A M.]]
+[[Category: Haapalainen AM]]
-[[Category: Ho, M C.]]
+[[Category: Ho MC]]
-[[Category: Schramm, V L.]]
+[[Category: Schramm VL]]
-[[Category: Suarez, J J.]]
+[[Category: Suarez JJ]]
-[[Category: Cytosol]]
-[[Category: Drug binding]]
-[[Category: Guanine]]
-[[Category: Intracellular]]
-[[Category: Nucleoside binding]]
-[[Category: Phosphate ion binding]]
-[[Category: Pnp]]
-[[Category: Purine base binding]]
-[[Category: Purine nucleoside phosphorylase]]
-[[Category: Purine-nucleoside phosphorylase activity]]
-[[Category: Transferase]]
-[[Category: Transferring glycosyl group]]