4dx5: Difference between revisions

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[[Image:4dx5.jpg|left|200px]]


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==Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop==
The line below this paragraph, containing "STRUCTURE_4dx5", creates the "Structure Box" on the page.
<StructureSection load='4dx5' size='340' side='right'caption='[[4dx5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4dx5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DX5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C14:TETRADECANE'>C14</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>
{{STRUCTURE_4dx5|  PDB=4dx5  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dx5 OCA], [https://pdbe.org/4dx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dx5 RCSB], [https://www.ebi.ac.uk/pdbsum/4dx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dx5 ProSAT]</span></td></tr>
 
</table>
===Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop===
== Function ==
 
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
 
== References ==
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[[Category: Escherichia coli K-12]]
{{ABSTRACT_PUBMED_22451937}}
[[Category: Large Structures]]
 
==About this Structure==
[[4dx5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX5 OCA].  
 
==Reference==
<ref group="xtra">PMID:022451937</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
[[Category: Bohnert, J A.]]
[[Category: Bohnert JA]]
[[Category: Brandstaetter, L.]]
[[Category: Brandstaetter L]]
[[Category: Cha, H.]]
[[Category: Cha H]]
[[Category: Diederichs, K.]]
[[Category: Diederichs K]]
[[Category: Eicher, T.]]
[[Category: Eicher T]]
[[Category: El-Delik, J.]]
[[Category: El-Delik J]]
[[Category: Gruetter, M G.]]
[[Category: Gruetter MG]]
[[Category: Kern, W V.]]
[[Category: Kern WV]]
[[Category: Pos, K M.]]
[[Category: Pos KM]]
[[Category: Seeger, M A.]]
[[Category: Seeger MA]]
[[Category: Verrey, F.]]
[[Category: Verrey F]]
[[Category: Darpin]]
[[Category: Membrane protein]]
[[Category: Multidrug efflux protein]]
[[Category: Transport protein]]

Latest revision as of 13:58, 1 March 2024

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loopTransport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Structural highlights

4dx5 is a 5 chain structure with sequence from Escherichia coli K-12 and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, , , , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACRB_ECOLI AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

References

  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

4dx5, resolution 1.90Å

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