4dm6: Difference between revisions

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[[Image:4dm6.png|left|200px]]


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==Crystal structure of RARb LBD homodimer in complex with TTNPB==
The line below this paragraph, containing "STRUCTURE_4dm6", creates the "Structure Box" on the page.
<StructureSection load='4dm6' size='340' side='right'caption='[[4dm6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4dm6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DM6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTB:4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC+ACID'>TTB</scene></td></tr>
{{STRUCTURE_4dm6|  PDB=4dm6  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dm6 OCA], [https://pdbe.org/4dm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dm6 RCSB], [https://www.ebi.ac.uk/pdbsum/4dm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dm6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RARB_HUMAN RARB_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.<ref>PMID:12554770</ref>


===Crystal structure of RARb LBD homodimer in complex with TTNPB===
==See Also==
 
*[[Retinoic acid receptor 3D structures|Retinoic acid receptor 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_22355136}}
 
==About this Structure==
[[4dm6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DM6 OCA].
 
==Reference==
<ref group="xtra">PMID:022355136</ref><references group="xtra"/>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bourguet, W.]]
[[Category: Large Structures]]
[[Category: Brelivet, Y.]]
[[Category: Bourguet W]]
[[Category: Cura, V.]]
[[Category: Brelivet Y]]
[[Category: Eiler, S.]]
[[Category: Cura V]]
[[Category: Moras, D.]]
[[Category: Eiler S]]
[[Category: Osz, J.]]
[[Category: Moras D]]
[[Category: Peluso-Iltis, C.]]
[[Category: Osz J]]
[[Category: Rochel, N.]]
[[Category: Peluso-Iltis C]]
[[Category: Ruff, M.]]
[[Category: Rochel N]]
[[Category: Alpha helical sandwich]]
[[Category: Ruff M]]
[[Category: Nuclear receptor]]
[[Category: Nucleus - cytoplasm]]
[[Category: Retinoic acid]]
[[Category: Retinoic acid binding]]
[[Category: Transcription]]
[[Category: Transcription regulator]]
[[Category: Transcription-protein binding complex]]

Latest revision as of 13:50, 1 March 2024

Crystal structure of RARb LBD homodimer in complex with TTNPBCrystal structure of RARb LBD homodimer in complex with TTNPB

Structural highlights

4dm6 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RARB_HUMAN Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.[1]

See Also

References

  1. ↑ Hauksdottir H, Farboud B, Privalsky ML. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol Endocrinol. 2003 Mar;17(3):373-85. Epub 2002 Dec 23. PMID:12554770 doi:10.1210/me.2002-0340

4dm6, resolution 1.90Å

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