4dk8: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:4dk8.png|left|200px]]
-<!--
+==Crystal structure of LXR ligand binding domain in complex with partial agonist 5==
-The line below this paragraph, containing "STRUCTURE_4dk8", creates the "Structure Box" on the page.
+<StructureSection load='4dk8' size='340' side='right'caption='[[4dk8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[4dk8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KT:N-METHYL-N-(4-{(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-[1-(2-METHOXYETHYL)-1H-PYRROL-2-YL]ETHYL}PHENYL)BENZENESULFONAMIDE'>0KT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-{{STRUCTURE_4dk8|  PDB=4dk8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk8 OCA], [https://pdbe.org/4dk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
-===Crystal structure of LXR ligand binding domain in complex with partial agonist 5===
+==See Also==
+*[[Liver X receptor|Liver X receptor]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_22406115}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 22406115 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_22406115}}
-==About this Structure==
-[[4dk8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK8 OCA].
-==Reference==
-<ref group="xtra">PMID:022406115</ref><references group="xtra"/>
-[[Category: Histone acetyltransferase]]
 [[Category: Homo sapiens]]
-[[Category: Kopecky, D J.]]
+[[Category: Large Structures]]
-[[Category: Piper, D E.]]
+[[Category: Kopecky DJ]]
-[[Category: Xu, H.]]
+[[Category: Piper DE]]
-[[Category: Ligand binding domain]]
+[[Category: Xu H]]
-[[Category: Nuclear hormone receptor]]
-[[Category: Transcription-peptide-agonist complex]]