4de5: Difference between revisions

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[[Image:4de5.jpg|left|200px]]


{{STRUCTURE_4de5| PDB=4de5 | SCENE= }}
==Pantothenate synthetase in complex with fragment 6==
<StructureSection load='4de5' size='340' side='right'caption='[[4de5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4de5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DE5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JD:(2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC+ACID'>0JD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4de5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4de5 OCA], [https://pdbe.org/4de5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4de5 RCSB], [https://www.ebi.ac.uk/pdbsum/4de5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4de5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>


===Pantothenate synthetase in complex with fragment 6===
==See Also==
 
*[[Pantothenate synthetase|Pantothenate synthetase]]
 
== References ==
==About this Structure==
<references/>
[[4de5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE5 OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Silvestre HL]]
[[Category: Silvestre, H L.]]
[[Category: Alpha beta/adenine nucleotide alpha hydrolase-like]]
[[Category: Fragment-based drug discovery]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Pantoate and b-ala binding]]
[[Category: Pantoate-beta-alanine ligase]]
[[Category: Protein in complex with fragment]]

Latest revision as of 13:44, 1 March 2024

Pantothenate synthetase in complex with fragment 6Pantothenate synthetase in complex with fragment 6

Structural highlights

4de5 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PANC_MYCTU Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]

See Also

References

  1. ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

4de5, resolution 2.25Å

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