408d: Difference between revisions

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[[Image:408d.gif|left|200px]]


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==STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA==
The line below this paragraph, containing "STRUCTURE_408d", creates the "Structure Box" on the page.
<StructureSection load='408d' size='340' side='right'caption='[[408d]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[408d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=408D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=408D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPY:IMIDAZOLE-PYRROLE+POLYAMIDE'>IPY</scene></td></tr>
{{STRUCTURE_408d|  PDB=408d  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=408d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=408d OCA], [https://pdbe.org/408d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=408d RCSB], [https://www.ebi.ac.uk/pdbsum/408d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=408d ProSAT]</span></td></tr>
 
</table>
'''STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Baird EE]]
Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates among all four Watson-Crick base pairs in the minor groove. The crystal structure of a specific polyamide dimer-DNA complex establishes the structural basis for distinguishing T.A from A.T base pairs. Specificity for the T.A base pair is achieved by means of distinct hydrogen bonds between pairs of substituted pyrroles on the ligand and the O2 of thymine and N3 of adenine. In addition, shape-selective recognition of an asymmetric cleft between the thymine-O2 and the adenine-C2 was observed. Although hitherto similarities among the base pairs in the minor groove have been emphasized, the structure illustrates differences that allow specific minor groove recognition.
[[Category: Dervan PB]]
 
[[Category: Kielkopf CL]]
==About this Structure==
[[Category: Rees DC]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=408D OCA].  
[[Category: Szewczyk JW]]
 
[[Category: Turner JM]]
==Reference==
[[Category: White S]]
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA., Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC, Science. 1998 Oct 2;282(5386):111-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9756473 9756473]
[[Category: Baird, E E.]]
[[Category: Dervan, P B.]]
[[Category: Kielkopf, C L.]]
[[Category: Rees, D C.]]
[[Category: Szewczyk, J W.]]
[[Category: Turner, J M.]]
[[Category: White, S.]]
[[Category: Drug in the dna minor groove]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:16:22 2008''

Latest revision as of 13:36, 1 March 2024

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNASTRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

Structural highlights

408d is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

408d, resolution 2.10Å

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