3ve6: Difference between revisions

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-[[Image:3ve6.jpg|left|200px]]
-<!--
+==Crystal Structure Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein NLS and Importin Alpha==
-The line below this paragraph, containing "STRUCTURE_3ve6", creates the "Structure Box" on the page.
+<StructureSection load='3ve6' size='340' side='right'caption='[[3ve6]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ve6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Venezuelan_equine_encephalitis_virus Venezuelan equine encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VE6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.829&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ve6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ve6 OCA], [https://pdbe.org/3ve6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ve6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ve6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ve6 ProSAT]</span></td></tr>
-{{STRUCTURE_3ve6|  PDB=3ve6  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
-===Crystal Structure Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein NLS and importin alpha===
+==See Also==
+*[[Importin 3D structures|Importin 3D structures]]
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-==About this Structure==
+__TOC__
-[[3ve6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VE6 OCA].
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Fan, F.]]
-[[Category: Capsid protein nl]]
-[[Category: Importin]]
-[[Category: Importin alpha]]
-[[Category: Protein binding]]
 [[Category: Venezuelan equine encephalitis virus]]
+[[Category: Fan F]]