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New page: '''Unreleased structure''' The entry 3us3 is ON HOLD Authors: Sanchez, E.J., Lewis, K.M., Nissen, M.S., Munske, G.R., Kang, C. Description: Recombinant rabbit skeletal calsequestrin-MP... |
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==Recombinant rabbit skeletal calsequestrin-MPD complex== | |||
<StructureSection load='3us3' size='340' side='right'caption='[[3us3]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3us3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3US3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3US3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.738Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3us3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3us3 OCA], [https://pdbe.org/3us3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3us3 RCSB], [https://www.ebi.ac.uk/pdbsum/3us3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3us3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CASQ1_RABIT CASQ1_RABIT] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Kang C]] | |||
[[Category: Lewis KM]] | |||
[[Category: Munske GR]] | |||
[[Category: Nissen MS]] | |||
[[Category: Sanchez EJ]] | |||
Latest revision as of 13:27, 1 March 2024
Recombinant rabbit skeletal calsequestrin-MPD complexRecombinant rabbit skeletal calsequestrin-MPD complex
Structural highlights
FunctionCASQ1_RABIT Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). |
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