3uj4: Difference between revisions

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-[[Image:3uj4.png|left|200px]]
-{{STRUCTURE_3uj4|  PDB=3uj4  |  SCENE=  }}
+==Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor==
+<StructureSection load='3uj4' size='340' side='right'caption='[[3uj4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-===Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3uj4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJ4 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_22286060}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uj4 OCA], [https://pdbe.org/3uj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uj4 RCSB], [https://www.ebi.ac.uk/pdbsum/3uj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uj4 ProSAT]</span></td></tr>
-[[3uj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ4 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
 ==See Also==
 *[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:022286060</ref><references group="xtra"/>
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Ikura, M.]]
+[[Category: Ikura M]]
-[[Category: Ishiyama, N.]]
+[[Category: Ishiyama N]]
-[[Category: Seo, M D.]]
+[[Category: Seo MD]]
-[[Category: Stathopulos, P.]]
+[[Category: Stathopulos P]]
-[[Category: 5-trisphosphate]]
-[[Category: Apo-state]]
-[[Category: Inositol 1]]
-[[Category: Ip3-binding core domain]]
-[[Category: Signaling protein]]
-[[Category: Suppressor domain]]