3uj0: Difference between revisions
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==Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.== | |||
<StructureSection load='3uj0' size='340' side='right'caption='[[3uj0]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3uj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJ0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uj0 OCA], [https://pdbe.org/3uj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uj0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | |||
==See Also== | |||
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Ikura M]] | |||
[[Category: Ishiyama N]] | |||
[[Category: Seo MD]] | |||
[[Category: Stathopulos P]] | |||
Latest revision as of 13:23, 1 March 2024
Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.
Structural highlights
FunctionITPR1_RAT Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). See Also |
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