3uel: Difference between revisions

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-[[Image:3uel.jpg|left|200px]]
-<!--
+==Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase bound to ADP-HPD==
-The line below this paragraph, containing "STRUCTURE_3uel", creates the "Structure Box" on the page.
+<StructureSection load='3uel' size='340' side='right'caption='[[3uel]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3uel]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UEL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1R:5-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE'>A1R</scene></td></tr>
-{{STRUCTURE_3uel|  PDB=3uel  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uel OCA], [https://pdbe.org/3uel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uel RCSB], [https://www.ebi.ac.uk/pdbsum/3uel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uel ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARG_RAT PARG_RAT] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
-===Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase bound to ADP-HPD===
+==See Also==
+*[[Poly(ADP-ribose) glycohydrolase 3D structures|Poly(ADP-ribose) glycohydrolase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3uel]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEL OCA].
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Classen, S.]]
+[[Category: Classen S]]
-[[Category: Ellenberger, T.]]
+[[Category: Ellenberger T]]
-[[Category: Kiefer, J R.]]
+[[Category: Kiefer JR]]
-[[Category: Kim, I K.]]
+[[Category: Kim IK]]
-[[Category: Stegemann, R A.]]
+[[Category: Stegemann RA]]
-[[Category: Tainer, J A.]]
+[[Category: Tainer JA]]
-[[Category: Adp-hpd]]
-[[Category: Hydrolase]]
-[[Category: Macrodomain]]
-[[Category: Mammalian parg]]