3uek: Difference between revisions

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-'''Unreleased structure'''
-The entry 3uek is ON HOLD  until Paper Publication
+==Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase==
+<StructureSection load='3uek' size='340' side='right'caption='[[3uek]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3uek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UEK FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uek OCA], [https://pdbe.org/3uek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uek RCSB], [https://www.ebi.ac.uk/pdbsum/3uek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uek ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARG_RAT PARG_RAT] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
-Authors: Kim, I.K., Kiefer, J.R., Stegemann, R.A., Classen, S., Tainer, J.A., Ellenberger, T.
+==See Also==
+*[[Poly(ADP-ribose) glycohydrolase 3D structures|Poly(ADP-ribose) glycohydrolase 3D structures]]
-Description: Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Classen S]]
+[[Category: Ellenberger T]]
+[[Category: Kiefer JR]]
+[[Category: Kim IK]]
+[[Category: Stegemann RA]]
+[[Category: Tainer JA]]