3ud3: Difference between revisions

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[[Image:3ud3.png|left|200px]]


{{STRUCTURE_3ud3| PDB=3ud3 | SCENE= }}
==The C92U mutant c-di-GMP-I riboswitch bound to pGpA==
<StructureSection load='3ud3' size='340' side='right'caption='[[3ud3]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ud3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UD3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ud3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ud3 OCA], [https://pdbe.org/3ud3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ud3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ud3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ud3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>


===The C92U mutant c-di-GMP-I riboswitch bound to pGpA===
==See Also==
 
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
{{ABSTRACT_PUBMED_22148472}}
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[3ud3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UD3 OCA].
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:022148472</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Smith, K D.]]
[[Category: Large Structures]]
[[Category: Strobel, S A.]]
[[Category: Vibrio cholerae]]
[[Category: Riboswitch]]
[[Category: Smith KD]]
[[Category: Signaling protein-rna complex]]
[[Category: Strobel SA]]

Latest revision as of 13:21, 1 March 2024

The C92U mutant c-di-GMP-I riboswitch bound to pGpAThe C92U mutant c-di-GMP-I riboswitch bound to pGpA

Structural highlights

3ud3 is a 3 chain structure with sequence from Homo sapiens and Vibrio cholerae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNRPA_HUMAN Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1]

See Also

References

  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

3ud3, resolution 3.10Å

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