3u0c: Difference between revisions

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-[[Image:3u0c.png|left|200px]]
-<!--
+==Crystal structure of N-terminal region of Type III Secretion First Translocator IpaB (residues 74-224)==
-The line below this paragraph, containing "STRUCTURE_3u0c", creates the "Structure Box" on the page.
+<StructureSection load='3u0c' size='340' side='right'caption='[[3u0c]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3u0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0C FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0c OCA], [https://pdbe.org/3u0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0c RCSB], [https://www.ebi.ac.uk/pdbsum/3u0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0c ProSAT]</span></td></tr>
-{{STRUCTURE_3u0c|  PDB=3u0c  |  SCENE=  }}
+</table>
+== Function ==
-===Crystal structure of N-terminal region of Type III Secretion First Translocator IpaB (residues 74-224)===
+[https://www.uniprot.org/uniprot/IPAB_SHIFL IPAB_SHIFL] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell contact. This pore probably allows the translocation of IpaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important, along with IpaD, to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal, respectively. Through interaction with host human MAD2L2, constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization.<ref>PMID:17719540</ref> <ref>PMID:9009343</ref>
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3u0c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0C OCA].
+</StructureSection>
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:022321794</ref><references group="xtra"/>
 [[Category: Shigella flexneri]]
-[[Category: Barta, M L.]]
+[[Category: Barta ML]]
-[[Category: Geisbrecht, B V.]]
+[[Category: Geisbrecht BV]]
-[[Category: Cell invasion]]
-[[Category: Coiled-coil]]
-[[Category: Translocator]]
-[[Category: Type three secretion system]]
-[[Category: Virulence]]