3tx4: Difference between revisions

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-[[Image:3tx4.png|left|200px]]
-{{STRUCTURE_3tx4|  PDB=3tx4  |  SCENE=  }}
+==Crystal Structure of Mutant (C354A) M. tuberculosis LD-transpeptidase type 2==
+<StructureSection load='3tx4' size='340' side='right'caption='[[3tx4]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
-===Crystal Structure of Mutant (C354A) M. tuberculosis LD-transpeptidase type 2===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3tx4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TX4 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_23103390}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tx4 OCA], [https://pdbe.org/3tx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tx4 RCSB], [https://www.ebi.ac.uk/pdbsum/3tx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tx4 ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[3tx4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TX4 OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Amzel, L M.]]
+[[Category: Amzel LM]]
-[[Category: Bianchet, M A.]]
+[[Category: Bianchet MA]]
-[[Category: Erdemli, S.]]
+[[Category: Erdemli S]]
-[[Category: Gupta, R.]]
+[[Category: Gupta R]]
-[[Category: Lamichhane, G.]]
+[[Category: Lamichhane G]]
-[[Category: Peptidoglycan binding protein]]
-[[Category: Protein-peptidoglycan complex]]