3tvt: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Structural basis for Discs Large interaction with Pins==
==Structural basis for Discs Large interaction with Pins==
<StructureSection load='3tvt' size='340' side='right' caption='[[3tvt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3tvt' size='340' side='right'caption='[[3tvt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TVT FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TVT FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dlg1, l(1)dlg1, CG1725 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]), raps, pins, CG5692 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tvt RCSB], [http://www.ebi.ac.uk/pdbsum/3tvt PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvt OCA], [https://pdbe.org/3tvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tvt RCSB], [https://www.ebi.ac.uk/pdbsum/3tvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tvt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DLG1_DROME DLG1_DROME] During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.<ref>PMID:10884224</ref> <ref>PMID:12657668</ref> <ref>PMID:1651169</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Doe, C Q]]
[[Category: Large Structures]]
[[Category: Johnston, C A]]
[[Category: Doe CQ]]
[[Category: Prehoda, K E]]
[[Category: Johnston CA]]
[[Category: Antitumor protein-protein binding complex]]
[[Category: Prehoda KE]]
[[Category: Cell membrane]]
[[Category: Dlg]]
[[Category: Guanylate kinase]]
[[Category: Phosphorylation-dependent]]
[[Category: Src-homology-3]]

Latest revision as of 13:15, 1 March 2024

Structural basis for Discs Large interaction with PinsStructural basis for Discs Large interaction with Pins

Structural highlights

3tvt is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DLG1_DROME During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.[1] [2] [3]

References

  1. ↑ Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 2000 Jul 7;289(5476):113-6. PMID:10884224
  2. ↑ Mendoza C, Olguin P, Lafferte G, Thomas U, Ebitsch S, Gundelfinger ED, Kukuljan M, Sierralta J. Novel isoforms of Dlg are fundamental for neuronal development in Drosophila. J Neurosci. 2003 Mar 15;23(6):2093-101. PMID:12657668
  3. ↑ Woods DF, Bryant PJ. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell. 1991 Aug 9;66(3):451-64. PMID:1651169

3tvt, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3tvt&oldid=4072099"