3tti: Difference between revisions
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< | ==Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor== | ||
<StructureSection load='3tti' size='340' side='right'caption='[[3tti]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
or the | <table><tr><td colspan='2'>[[3tti]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TTI FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KBI:TRANS-4-({9-[(3S)-TETRAHYDROFURAN-3-YL]-8-[(2,4,6-TRIFLUOROPHENYL)AMINO]-9H-PURIN-2-YL}AMINO)CYCLOHEXANOL'>KBI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tti OCA], [https://pdbe.org/3tti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tti RCSB], [https://www.ebi.ac.uk/pdbsum/3tti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tti ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[https://omim.org/entry/606369 606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref> | |||
== | ==See Also== | ||
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Albers | [[Category: Albers R]] | ||
[[Category: Ayala | [[Category: Ayala L]] | ||
[[Category: Bahmanyar | [[Category: Bahmanyar S]] | ||
[[Category: Bai | [[Category: Bai A]] | ||
[[Category: Benish | [[Category: Benish B]] | ||
[[Category: Bennett | [[Category: Bennett B]] | ||
[[Category: Blease | [[Category: Blease K]] | ||
[[Category: Bodine | [[Category: Bodine T]] | ||
[[Category: Cathers | [[Category: Cathers BE]] | ||
[[Category: Celeridad | [[Category: Celeridad M]] | ||
[[Category: Chamberlain | [[Category: Chamberlain P]] | ||
[[Category: Clareen | [[Category: Clareen S]] | ||
[[Category: Delgado | [[Category: D'Sidocky N]] | ||
[[Category: Delker | [[Category: Delgado M]] | ||
[[Category: Fan | [[Category: Delker SL]] | ||
[[Category: Giegel | [[Category: Fan R]] | ||
[[Category: Hegde | [[Category: Giegel D]] | ||
[[Category: Hilgraf | [[Category: Hegde S]] | ||
[[Category: Katz | [[Category: Hilgraf R]] | ||
[[Category: Khatsenko | [[Category: Katz J]] | ||
[[Category: Lachowitzer | [[Category: Khatsenko O]] | ||
[[Category: McCarrick | [[Category: Lachowitzer J]] | ||
[[Category: Moghaddam | [[Category: McCarrick M]] | ||
[[Category: Muir | [[Category: Moghaddam M]] | ||
[[Category: Nadolny | [[Category: Muir J]] | ||
[[Category: Plantevin-Krenitsky | [[Category: Nadolny L]] | ||
[[Category: Raymon | [[Category: Plantevin-Krenitsky V]] | ||
[[Category: Sapienza | [[Category: Raymon H]] | ||
[[Category: Satoh | [[Category: Sapienza J]] | ||
[[Category: Shirley | [[Category: Satoh Y]] | ||
[[Category: Shirley MA]] | |||
[[Category: Tang | [[Category: Tang Y]] | ||
[[Category: Wright | [[Category: Wright J]] | ||
[[Category: Xu | [[Category: Xu L]] | ||