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==Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin==
==Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin==
<StructureSection load='3ts5' size='340' side='right' caption='[[3ts5]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
<StructureSection load='3ts5' size='340' side='right'caption='[[3ts5]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ts5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Placopecten_magellanicus Placopecten magellanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TS5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ts5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Placopecten_magellanicus Placopecten magellanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TS5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.393&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tuy|3tuy]], [[3pn7|3pn7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts5 OCA], [http://pdbe.org/3ts5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ts5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ts5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ts5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts5 OCA], [https://pdbe.org/3ts5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ts5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ts5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts5 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q26080_PLAMG Q26080_PLAMG]
We have determined the crystal structure of a phosphorylated smooth-muscle myosin light chain domain (LCD). This reconstituted LCD is of a sea scallop catch muscle myosin with its phosphorylatable regulatory light chain (RLC SmoA). In the crystal structure, Arg(16), an arginine residue that is present in this isoform but not in vertebrate smooth-muscle RLC, stabilizes the phosphorylation site. This arginine interacts with the carbonyl group of the phosphorylation-site serine in the unphosphorylated LCD (determined previously), and with the phosphate group when the serine is phosphorylated. However, the overall conformation of the LCD is essentially unchanged upon phosphorylation. This result provides additional evidence that phosphorylation of the RLC is unlikely to act as an on-switch in regulation of scallop catch muscle myosin.
 
Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle Myosin.,Senthil Kumar VS, O'Neall-Hennessey E, Reshetnikova L, Brown JH, Robinson H, Szent-Gyorgyi AG, Cohen C Biophys J. 2011 Nov 2;101(9):2185-9. Epub 2011 Nov 1. PMID:22067157<ref>PMID:22067157</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ts5" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Myosin|Myosin]]
*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Placopecten magellanicus]]
[[Category: Placopecten magellanicus]]
[[Category: Brown, J H]]
[[Category: Brown JH]]
[[Category: Cohen, C]]
[[Category: Cohen C]]
[[Category: Kumar, V S.S]]
[[Category: Kumar VSS]]
[[Category: Neall-Hennessey, E O]]
[[Category: O'Neall-Hennessey E]]
[[Category: Reshetnikova, L]]
[[Category: Reshetnikova L]]
[[Category: Robinson, H]]
[[Category: Robinson H]]
[[Category: Szent-Gyorgyi, A G]]
[[Category: Szent-Gyorgyi AG]]
[[Category: Alpha helix]]
[[Category: Catch muscle]]
[[Category: Myosin regulation]]
[[Category: Structural protein]]

Latest revision as of 13:11, 1 March 2024

Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle MyosinCrystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin

Structural highlights

3ts5 is a 6 chain structure with sequence from Placopecten magellanicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.393Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q26080_PLAMG

See Also

3ts5, resolution 2.39Å

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