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==Structure of Mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamate==
==Structure of Mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamate==
<StructureSection load='3tao' size='340' side='right' caption='[[3tao]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='3tao' size='340' side='right'caption='[[3tao]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tao]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TAO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TAO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGH:PHOSPHOGLYCOLOHYDROXAMIC+ACID'>PGH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gvg|3gvg]], [[3ta6|3ta6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGH:PHOSPHOGLYCOLOHYDROXAMIC+ACID'>PGH</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT1482, MTCY493.16c, Rv1438, tpi, tpiA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tao OCA], [https://pdbe.org/3tao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tao RCSB], [https://www.ebi.ac.uk/pdbsum/3tao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tao ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tao RCSB], [http://www.ebi.ac.uk/pdbsum/3tao PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/TPIS_MYCTU TPIS_MYCTU]
Tuberculosis (TB) is a major infectious disease that accounts for over 1.7 million deaths every year. Mycobacterium tuberculosis, the causative agent of tuberculosis, enters the human host by the inhalation of infectious aerosols. Additionally, one third of the world's population is likely to be infected with latent TB. The incidence of TB is on the rise owing in part to the emergence of multidrug-resistant strains. As a result, there is a growing need to focus on novel M. tuberculosis enzyme targets. M. tuberculosis triosephosphate isomerase (MtTPI) is an essential enzyme for gluconeogenetic pathways, making it a potential target for future therapeutics. In order to determine its structure, the X-ray crystal structure of MtTPI has been determined, as well as that of MtTPI bound with a reaction-intermediate analog. As a result, two forms of the active site were revealed. In conjunction with the kinetic parameters obtained for the MtTPI-facilitated conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (D-GAP), this provides a greater structural and biochemical understanding of this enzyme. Additionally, isothermal titration calorimetry was used to determine the binding constant for a reaction-intermediate analog bound to the active site of MtTPI.
 
Structural and functional characterization of Mycobacterium tuberculosis triosephosphate isomerase.,Connor SE, Capodagli GC, Deaton MK, Pegan SD Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1017-22. Epub 2011 Nov 5. PMID:22120738<ref>PMID:22120738</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


==See Also==
==See Also==
*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium tuberculosis]]
[[Category: Large Structures]]
[[Category: Triose-phosphate isomerase]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Capodagli, G C]]
[[Category: Capodagli GC]]
[[Category: Connor, S E]]
[[Category: Connor SE]]
[[Category: Deaton, M K]]
[[Category: Deaton MK]]
[[Category: Pegan, S D]]
[[Category: Pegan SD]]
[[Category: Isomerase]]

Latest revision as of 13:07, 1 March 2024

Structure of Mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamateStructure of Mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamate

Structural highlights

3tao is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TPIS_MYCTU

See Also

3tao, resolution 1.45Å

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