3t5x: Difference between revisions

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[[Image:3t5x.png|left|200px]]


{{STRUCTURE_3t5x|  PDB=3t5x  |  SCENE=  }}
==PCID2:DSS1 Structure==
 
<StructureSection load='3t5x' size='340' side='right'caption='[[3t5x]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
===PCID2:DSS1 Structure===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3t5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5X FirstGlance]. <br>
{{ABSTRACT_PUBMED_22343721}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.123&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5x OCA], [https://pdbe.org/3t5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5x RCSB], [https://www.ebi.ac.uk/pdbsum/3t5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5x ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3t5x]] is a 2 chain structure of [[Proteasome]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5X OCA].  
== Function ==
[https://www.uniprot.org/uniprot/PCID2_HUMAN PCID2_HUMAN] Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.<ref>PMID:22307388</ref> <ref>PMID:24896180</ref>


==See Also==
==See Also==
*[[Proteasome|Proteasome]]
*[[Proteasome 3D structures|Proteasome 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022343721</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ellisdon, A M.]]
[[Category: Large Structures]]
[[Category: Stewart, M.]]
[[Category: Ellisdon AM]]
[[Category: Mrna nuclear export]]
[[Category: Stewart M]]
[[Category: Pci]]
[[Category: Transcription]]

Latest revision as of 13:04, 1 March 2024

PCID2:DSS1 StructurePCID2:DSS1 Structure

Structural highlights

3t5x is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.123Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PCID2_HUMAN Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.[1] [2]

See Also

References

  1. ↑ Jani D, Lutz S, Hurt E, Laskey RA, Stewart M, Wickramasinghe VO. Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res. 2012 May 1;40(10):4562-73. Epub 2012 Feb 4. PMID:22307388 doi:10.1093/nar/gks059
  2. ↑ Bhatia V, Barroso SI, Garcia-Rubio ML, Tumini E, Herrera-Moyano E, Aguilera A. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. Nature. 2014 Jul 17;511(7509):362-5. doi: 10.1038/nature13374. Epub 2014 Jun 1. PMID:24896180 doi:http://dx.doi.org/10.1038/nature13374

3t5x, resolution 2.12Å

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